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BSA催化的Gewald反应


Bovine serum albumin-catalyzed one-pot synthesis of 2-aminothiophenes via Gewald reaction


Publication date: November 2013
Source:Journal of Molecular Catalysis B: Enzymatic, Volume 95

Author(s): Dan-Dan Zhao , Li Li , Fan Xu , Qi Wu , Xian-Fu Lin

A novel bovine serum albumin (BSA)-catalyzed Gewald reaction in one-pot was developed in this work. The influence of reaction conditions including solvent, temperature and catalyst loading was investigated, and 12 multi-substituted 2-aminothiophene derivatives were prepared with moderate to excellent yields. Recycle experiments were designed to demonstrate the reusability of BSA. This novel activity of BSA to catalyze Gewald reaction is of practical significance in expanding the application of biocatalysts. 

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