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生物催化的第三次浪潮



Engineering the third wave of biocatalysis

Nature 485,185–194Date (10 May 2012)  doi:10.1038/nature11117 



Over the past ten years, scientific and technological advances have established biocatalysis as a practical and environmentally friendly alternative to traditional metallo- and organocatalysis in chemical synthesis, both in the laboratory and on an industrial scale. Key advances in DNA sequencing and gene synthesis are at the base of tremendous progress in tailoring biocatalysts by protein engineering and design, and the ability to reorganize enzymes into new biosynthetic pathways. To highlight these achievements, here we discuss applications of protein-engineered biocatalysts ranging from commodity chemicals to advanced pharmaceutical intermediates that use enzyme catalysis as a key step.


生物谷介绍了一篇近期发表在nature综述性文章,重点论述了生物催化技术在现代生物能源、生物材料等生物基化学品生产制造上的巨大优势和应用潜力,将成为生物技术的第三次革命。



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